The effects of gabapentin and pregabalin on fracture healing: A histological, radiological, and biomechanical analysis
These findings suggest that these drugs, particularly with their high-dose applications, may lead to prolonged inflammation and hinder fracture healing by reducing callus volume and biomechanical integrity, potentially disrupting the transition from the inflammatory to reparative phases of healing.
Authors
- Özgür Bulmuş (ORCID: https://orcid.org/0000-0001-7736-402X)
- Gülay Turan (ORCID: https://orcid.org/0000-0002-3702-8811)
- Emrah Özcan (ORCID: https://orcid.org/0000-0002-6373-4744)
- Ahmet Emrah Açan (ORCID: https://orcid.org/0000-0001-7116-8773)
- R. Buğra Hüsemoğlu (ORCID: https://orcid.org/0000-0003-1979-160X)
- Aslı Karakılıç (ORCID: https://orcid.org/0000-0001-7788-4949)
- Memduh Aydın (ORCID: https://orcid.org/0009-0006-6124-7842)
Institutions
- Balıkesir University (TR)
- Erzincan Binali Yıldırım University (TR)
- Dokuz Eylül University (TR)
Publication Details
- Journal
- Joint Diseases and Related Surgery
- Published
- 2024-12-18
- DOI
- https://doi.org/10.52312/jdrs.2025.2042
- Citations
- 2
- Primary Topic
- Orthopaedic implants and arthroplasty
- Type
- article
- Field-Weighted Citation Impact
- 1.15