Activity of DNA Repair Systems in Cells of Long-Lived Rodents and Bats (Review)

The accumulation of damage in the genomic DNA of various origins can lead to a violation of its stability, which is considered as one of the main causes of cell aging. DNA repair systems available in mammalian cells ensure effective removal of damage and restoration of the genome structure, and therefore it is assumed that the activity of these systems may be interrelated with the high maximum life expectancy observed in long-lived mammals. The review discusses the currently available results of work on determining the activity of DNA repair systems and studying the properties of key regulatory proteins of this process in the cells of long-lived rodents and bats. Based on the studies reviewed in the review, it can be concluded that long-lived rodents and bats, in general, demonstrate high efficiency in the functioning and regulation of DNA repair systems. Nevertheless, in the context of studying DNA repair in the cells of long-lived rodents and bats, there are still a number of insufficiently studied issues that open up prospects for further research.