Crosstalk between cancer-associated fibroblasts and non-neuroendocrine tumor cells in small cell lung cancer involves in glycolysis and antigen-presenting features
Our findings suggest that crosstalk between CAFs and non-NE SCLC cells promotes glycolysis in non-NE SCLC cells, thereby increase T cell chemo-attractant expression via activating STING signaling. On the other hand, it promotes the presence of apCAFs, which probably contributes to CD8 + T cell trapping and Treg differentiation. This study emphasizes the pro-tumor function of CAFs in SCLC by promoting glycolysis and impairing T cell function, providing direction for the development of novel therapeutic approaches targeting CAF in SCLC.
Authors
- Yuanhua Lu (ORCID: https://orcid.org/0000-0002-4757-8390)
- Peiyan Zhao (ORCID: https://orcid.org/0000-0002-6977-339X)
- Rui Zhong (ORCID: https://orcid.org/0000-0003-4570-0927)
- Lin Tian
- Haifeng Liu (ORCID: https://orcid.org/0000-0002-0538-8150)
- Hui Li (ORCID: https://orcid.org/0000-0001-6214-8308)
- Yan Liu
- Ying Cheng (ORCID: https://orcid.org/0000-0002-8940-8445)
- Wenjun Shao
- Xinyue Wang (ORCID: https://orcid.org/0000-0003-2986-7735)
Institutions
- Jilin Province Tumor Hospital (CN)
Publication Details
- Journal
- Molecular Medicine
- Published
- 2024-12-25
- DOI
- https://doi.org/10.1186/s10020-024-01051-y
- Citations
- 8
- Primary Topic
- Lung Cancer Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 2.26
Funders
- China Association for Science and Technology
- National Natural Science Foundation of China
- People's Government of Jilin Province
- Department of Science and Technology of Jilin Province
- Health Commission of Jilin Province