Synthesis and Anti-Cancer Activity of New Spiro[5.5]undecane Compound by Efficient Microwave Reaction

Microwave-assisted organic synthesis has gained significant attention for speeding up reactions, improving yields, and reducing reaction times. In this study, we investigated the microwave-induced reaction between dimedone and (1E,4E)-1,5-bis(4-fluorophenyl)penta-1,4-dien-3-one to synthesize 7,11-bis(4-fluorophenyl)-3,3-dimethylspiro[5.5]undecane-1,5,9-trione. The reaction was conducted using a microwave irradiation system, which allowed for a more environmentally friendly and energy-efficient process. Key parameters such as reaction time, temperature, and power settings were optimized for maximum yield. The synthesized compound was characterized using spectroscopic methods, including IR, ¹H-NMR, ¹³C-NMR, and mass spectrometry. The same reaction was also performed using a conventional method at room temperature which took 2-3 hours. The microwave approach was preferred due to its efficiency. Our findings indicate that microwave irradiation significantly enhances reaction efficiency, offering a fast method for synthesizing complex organic molecules. This technique has potential applications in various fields, including pharmaceutical chemistry and materials science, with a growing demand for sustainable and efficient chemical processes. Additionally, we conducted an in vitro anti-cancer activity experiment to evaluate the synthesized compound’s biological activity.