Alterations in the gut microbiome and metabolism with doxorubicin-induced heart failure severity
Marked differences were found in the composition and abundance of gut microorganisms, the levels of serum metabolites and metabolic pathways in different degrees of DIHF. The intestinal bacteria were significantly correlated with differential metabolites in different degrees of DIHF. The gut microbiota may serve as new targets for the treatment of DIHF.
Authors
- Shuling Rong (ORCID: https://orcid.org/0000-0002-9490-4187)
- Xuedong Zhou (ORCID: https://orcid.org/0000-0002-9319-7302)
- Chenyang Wang
- Qian Wang (ORCID: https://orcid.org/0000-0003-4507-0523)
- Tong Liu (ORCID: https://orcid.org/0000-0003-1266-7905)
- Xiaolin Wang (ORCID: https://orcid.org/0000-0001-9171-4073)
- Long Li (ORCID: https://orcid.org/0000-0003-0358-3099)
- Meihua Liu (ORCID: https://orcid.org/0000-0001-6653-9568)
Institutions
- Shanxi Medical University (CN)
- Sichuan University (CN)
- Second Hospital of Shanxi Medical University (CN)
- State Key Laboratory of Oral Diseases
Publication Details
- Journal
- Frontiers in Microbiology
- Published
- 2024-12-24
- DOI
- https://doi.org/10.3389/fmicb.2024.1348403
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 0.00