Inhibition of phosphodiesterases 1 and 4 prevents myofibroblast transformation in Peyronie's disease
This is the first demonstration of the expression of PDE1, 7 and 8 isoforms, and the function of PDE1 and PDE4 in human TA fibroblasts. The ability of inhibitors of these enzymes to prevent myofibroblast transformation suggests that such inhibitors can be developed to treat acute PD.
Authors
- Selim Cellek (ORCID: https://orcid.org/0000-0002-4856-285X)
- Stephen A. Bustin (ORCID: https://orcid.org/0000-0003-1870-6098)
- Marcus M. Ilg (ORCID: https://orcid.org/0000-0003-0803-0610)
- David Ralph (ORCID: https://orcid.org/0000-0002-5063-4074)
- Sophie L. Harding
Institutions
- University College London (GB)
- Anglia Ruskin University (GB)
Publication Details
- Journal
- British Journal of Urology
- Published
- 2024-12-23
- DOI
- https://doi.org/10.1111/bju.16631
- Citations
- 2
- Primary Topic
- Sexual function and dysfunction studies
- Type
- article
- Field-Weighted Citation Impact
- 0.77