Fumarprotocetraric acid and geraniin were identified as novel inhibitors of human respiratory syncytial virus infection in vitro
FUM and GE were identified as new inhibitors of RSV infection. At the same time, FUM and GE have anti-inflammatory activity, mitochondrial protection function, and broad-spectrum antiviral activity. These results provide evidence that FUM and GE are potential candidates for the development of novel anti-RSV drugs.
Authors
- Yiman Huang (ORCID: https://orcid.org/0000-0002-8236-1154)
- Guanhua Du (ORCID: https://orcid.org/0000-0002-6896-0847)
- Lishu Zheng (ORCID: https://orcid.org/0000-0002-8780-6191)
- Yiming Bai (ORCID: https://orcid.org/0000-0003-4618-2586)
- Chao Wang (ORCID: https://orcid.org/0000-0002-0415-503X)
- Yan Chen (ORCID: https://orcid.org/0000-0003-3808-1259)
- Ailin Liu (ORCID: https://orcid.org/0000-0002-1989-103X)
- Jun Zhao (ORCID: https://orcid.org/0000-0002-5804-6816)
Institutions
- Chinese Center For Disease Control and Prevention (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- National Institute for Viral Disease Control and Prevention (CN)
Publication Details
- Journal
- Frontiers in Cellular and Infection Microbiology
- Published
- 2024-12-24
- DOI
- https://doi.org/10.3389/fcimb.2024.1484245
- Citations
- 7
- Primary Topic
- Respiratory viral infections research
- Type
- article
- Field-Weighted Citation Impact
- 2.71
Funders
- National Key Research and Development Program of China