Case report: Aggressive NSCLC with partial BRG-1 deficiency and KRAS G12C mutation: a case study and treatment challenges
Partial BRG-1 deficiency may lead to aggressive clinical behavior, similar to complete BRG-1 loss. This case emphasizes the importance of comprehensive molecular profiling to guide treatment decisions and suggests further investigation into combined therapeutic strategies, including immunotherapy.
Authors
- Hong Ge (ORCID: https://orcid.org/0000-0003-4270-2556)
- Dongsheng Hou
- Mingming Tan
- Jing Li (ORCID: https://orcid.org/0000-0003-2476-9968)
- Chengwei Jin
Institutions
- Shandong Provincial Hospital (CN)
- Central Hospital of Zibo (CN)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2024-12-24
- DOI
- https://doi.org/10.3389/fonc.2024.1515240
- Primary Topic
- Chromatin Remodeling and Cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00