Emodin induced hepatic steatosis in BALb/c mice by modulating the gut microbiota composition and fatty acid metabolism
These findings further corroborate that emodin induces liver injury via the intestinal dysfunction. These findings suggested that emodin may disrupt intestinal microbiota and resulted in significant alternations in endogenous metabolites in mice, thereby facilitating the entry of LPS and FFAs into the liver, potentially leading to hepatic injury.
Authors
- Xinhua Xia (ORCID: https://orcid.org/0000-0003-2630-5585)
- Y. J. Liu
- X.Q. Hou (ORCID: https://orcid.org/0009-0001-9142-556X)
- Jinzhou Huang (ORCID: https://orcid.org/0000-0002-5956-0905)
- Mei Liu (ORCID: https://orcid.org/0000-0002-2547-1955)
- Lin Chen (ORCID: https://orcid.org/0000-0003-2237-8568)
- Xueling He
Institutions
- First Affiliated Hospital of Guangzhou Medical University (CN)
- Guangdong Provincial Hospital of Traditional Chinese Medicine (CN)
- Guangdong Institute for Drug Control (CN)
- Guangzhou Medical University (CN)
- Zhongkai University of Agriculture and Engineering (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2024-12-24
- DOI
- https://doi.org/10.3389/fphar.2024.1516272
- Citations
- 2
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 0.47