Immune complexes-mediated activation of neutrophils in systemic lupus erythematosus is dependent on RNA recognition by toll-like receptor 8
The data support IC-driven RNA-sensing by TLR8 in neutrophils is a key mechanism of neutrophil activation in SLE. Patients with elevated neutrophil activation and presence of RNA-containing ICs, may benefit from TLR8 inhibition and other strategies targeting RNA removal.
Authors
- Natasha K. Crellin
- Runa Kuley (ORCID: https://orcid.org/0000-0003-4773-6739)
- Jayamary Divya Ravichandar
- Gundula Min‐Oo
- Christian Lood (ORCID: https://orcid.org/0000-0002-6171-1952)
- Christopher W. Pohlmeyer (ORCID: https://orcid.org/0000-0002-4076-0309)
- Payton Hermanson
- Ping Chu
- Ting Wang (ORCID: https://orcid.org/0000-0002-8974-596X)
- David Arturo Juarez Lopez (ORCID: https://orcid.org/0009-0002-2310-3793)
- Ching Shang
Institutions
- Amgen (United States) (US)
- Mahindra Group (India) (IN)
- University of Washington (US)
- Gilead Sciences (United States) (US)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2024-12-24
- DOI
- https://doi.org/10.3389/fimmu.2024.1515469
- Citations
- 4
- Primary Topic
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.96
Funders
- Gilead Sciences