Ionizing radiation improves skin bacterial dysbiosis in cutaneous T-cell lymphoma
IR not only eliminates CTCL lesions via induction of apoptosis, but also facilitates skin barrier restoration and recolonization of bacterial taxa associated with a healthy skin microbiome. Local IR does not have as strong an effect on the skin microbiome as TSEBT. As skin microbiota act as immunomodulators with local and potentially systemic influence, TSEBT may also improve CTCL lesions via global effects on the skin microbiome. Future larger-scale studies are required to fully elucidate the relationship between cutaneous microbes and IR treatment in CTCL.
Authors
- Michael B. Burns (ORCID: https://orcid.org/0000-0001-9791-4359)
- Bharat B. Mittal (ORCID: https://orcid.org/0000-0002-6541-8753)
- G. Rajeev-Kumar (ORCID: https://orcid.org/0000-0002-2319-2012)
- Stefan J. Green (ORCID: https://orcid.org/0000-0003-2781-359X)
- Xiaolong Zhou (ORCID: https://orcid.org/0000-0002-6177-2472)
- Madeline J. Hooper (ORCID: https://orcid.org/0000-0003-1334-5342)
- Patrick C. Seed (ORCID: https://orcid.org/0000-0001-8998-8374)
- Joan Guitart (ORCID: https://orcid.org/0000-0001-7635-9237)
- Yanzhen Pang (ORCID: https://orcid.org/0000-0003-1825-9603)
- Lauren P. Chrisman (ORCID: https://orcid.org/0000-0002-2306-5697)
- Ralph R Weichselbaum
- Hua Liang (ORCID: https://orcid.org/0000-0003-3170-6922)
- William Nguyen (ORCID: https://orcid.org/0000-0003-1092-4859)
- Yasmin Hasan (ORCID: https://orcid.org/0009-0001-6607-5078)
Institutions
- Northwestern University (US)
- Rush University Medical Center (US)
- Lurie Children's Hospital (US)
- Loyola University Chicago (US)
- University of Chicago (US)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2024-12-24
- DOI
- https://doi.org/10.3389/fimmu.2024.1520214
- Citations
- 1
- Primary Topic
- Cutaneous lymphoproliferative disorders research
- Type
- article
- Field-Weighted Citation Impact
- 0.53
Funders
- Gilead Sciences
- Northwestern University
- Cutaneous Lymphoma Foundation
- Gilead Research Scholars
- National Institutes of Health