CD28 shapes T cell receptor signaling by regulating Lck dynamics and ZAP70 activation
These results suggest that CD28 co- stimulation may lower the TCR activation threshold by enhancing the activated form of Lck in the TCR MCs.
Authors
- Katherine M. McIntire (ORCID: https://orcid.org/0000-0002-6262-4260)
- Andy D. Tran (ORCID: https://orcid.org/0000-0002-2388-7121)
- Sandeep Pallikkuth (ORCID: https://orcid.org/0009-0003-0400-6389)
- Joseph A. Garvey (ORCID: https://orcid.org/0000-0003-3431-8773)
- Neriah Alvinez (ORCID: https://orcid.org/0009-0006-4704-2314)
- Kumarkrishna Raychaudhuri (ORCID: https://orcid.org/0000-0001-5198-8651)
- Jason Yi (ORCID: https://orcid.org/0000-0001-5131-6767)
- Lawrence E. Samelson (ORCID: https://orcid.org/0000-0002-5963-2112)
- Rohita Rangu
- Alison Ma
Institutions
- National Institutes of Health (US)
- National Cancer Institute (US)
- Center for Cancer Research (US)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2024-12-24
- DOI
- https://doi.org/10.3389/fimmu.2024.1503018
- Citations
- 4
- Primary Topic
- T-cell and B-cell Immunology
- Type
- article
- Field-Weighted Citation Impact
- 0.96
Funders
- National Institutes of Health
- National Heart, Lung, and Blood Institute
- National Cancer Institute