PGD2/PTGDR2 signaling pathway affects the self-renewal capacity of gastric cancer stem cells by regulating ATG4B ubiquitination
In summary, it was elucidated that the PGD2/PTGDR2 signaling cascade affects GCSCs stemness by regulating autophagy, suggesting that the PGD2/PTGDR2 signaling pathway could serve as a novel target for cancer therapy.
Authors
- Chaoqun Lian (ORCID: https://orcid.org/0000-0003-4914-020X)
- Qiang Zhang (ORCID: https://orcid.org/0000-0002-5923-2696)
- Lulu Wang (ORCID: https://orcid.org/0009-0006-2325-0733)
- Feifan Wang (ORCID: https://orcid.org/0009-0003-9599-5687)
- Hengjin Tian
- Kunpeng Ge
- Yanming Zhao
- Amin Chen
- Peiyao Gao
Institutions
- Bengbu Medical College (CN)
- The Second Affiliated Hospital of Bengbu Medical College (CN)
- Xian Yang Central Hospital (CN)
- First Affiliated Hospital of Bengbu Medical College (CN)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2024-12-24
- DOI
- https://doi.org/10.3389/fonc.2024.1496050
- Citations
- 5
- Primary Topic
- Cancer-related molecular mechanisms research
- Type
- article
- Field-Weighted Citation Impact
- 1.43
Funders
- Bengbu Medical College
- Natural Science Foundation of Anhui Province