Soluble factors released by peripheral blood-derived CAR-NK cells cause bystander myeloid cell activation
These data suggest that specific SFs released by PB-CAR-NK cells activate BMCs and have the potential to contribute to inflammatory toxicities. Furthermore, inactivation of these four factors in PB-CAR-NK cells could reduce inflammatory toxicities and improve safety of PB-CAR-NK cell therapy without compromising potency.
Authors
- Winston Colon‐Moran
- Alan N. Baer (ORCID: https://orcid.org/0000-0001-8344-013X)
- Supreet Khanal (ORCID: https://orcid.org/0000-0002-8483-9940)
- Santosh Panthi (ORCID: https://orcid.org/0000-0002-7610-088X)
- Nirjal Bhattarai (ORCID: https://orcid.org/0000-0003-1798-8863)
- Md Kamal Hossain
Institutions
- Center for Biologics Evaluation and Research (US)
- United States Food and Drug Administration (US)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2024-12-24
- DOI
- https://doi.org/10.3389/fimmu.2024.1519415
- Citations
- 3
- Primary Topic
- CAR-T cell therapy research
- Type
- article
- Field-Weighted Citation Impact
- 0.85
Funders
- U.S. Department of Energy
- Oak Ridge Institute for Science and Education
- Food and Drug Administration