PX-12 modulates vorinostat-induced acetylation and methylation marks in CAL 27 cells
Mass spectrometry-based proteomics highlighted the impact of vorinostat and PX-12 on histone acetylation and methylation, offering valuable insights into the epigenetic mechanisms in OSCC and paving a way for epigenetic-based oral cancer therapeutics.
Authors
- Tajwali Khan (ORCID: https://orcid.org/0000-0001-9531-3824)
- Syed Ghulam Musharraf (ORCID: https://orcid.org/0000-0003-2026-3302)
- Rafia Akhlaq
- Simone Sidoli (ORCID: https://orcid.org/0000-0001-9073-6641)
- Jazmine-Saskya N. Joseph-Chowdhury
- Arslan Ali (ORCID: https://orcid.org/0000-0001-5754-6483)
- Syed Usama Yaseen Jeelani (ORCID: https://orcid.org/0000-0002-6883-8489)
- Tehmina Ahmed
Institutions
- Albert Einstein College of Medicine (US)
- University of Karachi (PK)
- International Center for Chemical and Biological Sciences (PK)
Publication Details
- Journal
- Epigenomics
- Published
- 2024-12-23
- DOI
- https://doi.org/10.1080/17501911.2024.2441652
- Citations
- 3
- Primary Topic
- Histone Deacetylase Inhibitors Research
- Type
- article
- Field-Weighted Citation Impact
- 0.70
Funders
- Alexander von Humboldt-Stiftung
- University of Karachi
- Directorate for Biological Sciences