Development of Ascorbic Acid and Ferulic Acid-Loaded Anti-Aging Liposomal Gel

Aim: The present study aimed to formulate and evaluate ascorbic acid and ferulic acidcontaining liposomal gel for treating skin aging. Method: In this study, the thin film hydration technique was employed to create liposomes containing phosphatidylcholine and cholesterol that were stimulated with ascorbic acid and ferulic acid. The produced liposomes were evaluated for stability, zeta potential, and size, and liposomal gel was evaluated for spreadability, viscosity, and in vitro drug release. Results and Discussion: The optimized liposomes had a zeta potential of (-49) mV, a Polydispersity Index (PDI) of (0.488), a particle size of 1028 nm, and an entrapment efficiency of (90.20) %. On the other hand, the spreadability of liposomal gel was determined as 5.86 cm, and the percentage of drug release was recorded as 96.6%. Conclusion: To achieve a stable liposomal formulation, it was discovered that the preparation of liposomes containing ascorbic acid and ferulic acid and then dispensing it in the form of liposomal gel was an effective method. After a thorough assessment of liposomes and liposomal gel, it was determined that the latter might be effectively employed as a topical gel to treat aging skin.