Formulation, Development, and Optimization of Fast Dissolving Tablets Containing Tapentadol Hydrochloride
The study successfully developed and optimized Tapentadol fast-dissolving tablets using direct compression and response surface methodology. The TH5 formulation showed rapid disintegration and optimal drug release, with stability confirmed under ICH conditions. This highlights the importance of super disintegrants in FDT formulation for rapid action and patient compliance.
Authors
- Tanuj Hooda (ORCID: https://orcid.org/0000-0002-6701-586X)
- Jampala Rajkumar
- Chandrashekar Thalluri (ORCID: https://orcid.org/0000-0001-8859-8315)
- Shanmugarathinam Alagarsamy (ORCID: https://orcid.org/0000-0002-2213-3045)
- Mallikarjun Vasam (ORCID: https://orcid.org/0000-0002-6489-4723)
- Anubhav Dubey (ORCID: https://orcid.org/0000-0002-9089-4794)
- Amit Lather
Institutions
- Maharishi Markandeshwar University, Mullana (IN)
- Maharana Pratap University of Agriculture and Technology (IN)
- Assam Down Town University (IN)
Publication Details
- Journal
- Pharmaceutical Nanotechnology
- Published
- 2024-12-23
- DOI
- https://doi.org/10.2174/0122117385350217241122151638
- Primary Topic
- Drug Solubulity and Delivery Systems
- Type
- article
- Field-Weighted Citation Impact
- 0.00