Neural substrates underlying distinct dual cognitive syndromes in Parkinson's disease
We demonstrated distinctive impairments of dopaminergic frontostriatal deficits and cortical degeneration as neural bases for the dual-syndrome hypothesis. Our findings suggest that occipitoparietal lobe thinning occurs at a cognitively normal stage, and additional frontotemporal lobe thinning underlies impairments in the memory and visuospatial domains at the PD-MCI stage.
Authors
- Takashi Hanakawa (ORCID: https://orcid.org/0000-0003-3267-8214)
- Nishida Akira
- Masanori Sawamura (ORCID: https://orcid.org/0000-0002-9613-6230)
- Yosuke Taruno
- Etsuro Nakanishi (ORCID: https://orcid.org/0009-0006-9869-4988)
- Tomohisa Okada (ORCID: https://orcid.org/0000-0003-2312-5677)
- Atsushi Shima (ORCID: https://orcid.org/0000-0002-3068-4621)
- Koji Furukawa (ORCID: https://orcid.org/0000-0002-6696-5804)
- Yuji Nakamoto (ORCID: https://orcid.org/0000-0001-5783-8048)
- Ryosuke Takahashi
- Yasutaka Fushimi (ORCID: https://orcid.org/0000-0002-1982-3168)
- Koji Fujimoto (ORCID: https://orcid.org/0000-0003-1209-7949)
- Nobukatsu Sawamoto (ORCID: https://orcid.org/0000-0001-8695-0223)
- Yusuke Sakato
- Hodaka Yamakado
- Haruhi Sakamaki‐Tsukita (ORCID: https://orcid.org/0000-0001-9089-6389)
- Ikko Wada (ORCID: https://orcid.org/0009-0003-5180-6063)
- Daisuke Kambe (ORCID: https://orcid.org/0009-0006-4187-5729)
- Kenji Yoshimura (ORCID: https://orcid.org/0000-0001-5033-3346)
- Yuta Terada
Institutions
- Kyoto University (JP)
Publication Details
- Journal
- European Journal of Neurology
- Published
- 2024-12-24
- DOI
- https://doi.org/10.1111/ene.70022
- Citations
- 6
- Primary Topic
- Parkinson's Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 2.21
Funders
- Japan Agency for Medical Research and Development
- Nihon Medi-Physics
- Japan Society for the Promotion of Science
- Japan Science and Technology Agency
- Moonshot Research and Development Program