New Treatment Strategies of Type 1 Diabetes Mellitus

Diabetes mellitus is a serious metabolic disorder characterized by elevated blood glucose levels resulting from either autoimmune destruction of β-cells in the pancreatic islets or insulin resistance. Type 1 diabetes mellitus is currently managed with insulin therapy; however, long-term treatment is often associated with chronic complications such as limb amputation, blindness, and kidney failure. This review explores innovative therapeutic strategies for Type 1 diabetes mellitus based on a comprehensive literature search using PubMed and relevant keywords. The findings highlight several promising approaches, including gene therapy, trans-differentiation, enhancing the self-replication of β-cells, stem cell therapies, immunomodulatory agents, and herbal medicines, all of which show potential for improving disease management and reducing complications.