Neuropeptide Y and inflammatory indices in women after repeated cesarean section

One of the topical issues in obstetrics is the study of the causes of uterine contractile dysfunction underlying labor abnormalities and increased incidence of abdominal delivery. There is evidence in the literature of the effect of neuropeptide Y (NPY) on the contractility of uterine smooth muscle cells and uterine arteries. However, many questions regarding the functional role of NPY and its pathogenetic significance in the development of pregnancy complications remain unre-solved. Objective. To study the correlation between immunohistochemical expression of NPY in myome-trial biopsies and inflammation indices in patients with repeated cesarean section. Material and methods. A comprehensive examination of 22 women who delivered by repeated cesarean section at 37—41 weeks of pregnancy was conducted in the obstetric hospital of the Kursk State Healthcare Institution �Emergency Medical Care Hospital�. In addition to the analy-sis of objective, obstetric, ultrasound and Doppler data, immunohistochemical staining of uterine biopsies with polyclonal antibodies recognizing NPY was performed. Based on the general blood test investigation, inflammation indices (neutrophil to lymphocyte ratio and Garkavi index) were determined and their correlation with the degree of NPY expression was established. Results. NPY expression in decidual cells correlated positively with the neutrophil-lymphocyte ratio and negatively with the Garkavi index in the entire study group. Conclusion. Inflammatory and infectious processes in the uterus stimulate NPY expression, which subsequently affects the contractility of the myometrium. A high NPY level corresponds to the presence of severe inflammation and failure of the immune response, indicating an im-portant immunological role of this neuropeptide in the endometrium.