A new sesquiterpene from the heartwood of <i>Cordia trichotoma</i> (Vell.) Arráb. ex Steud
A new sesquiterpene, 8,11-epoxy-cadi-3,9-diene (<b>1</b>), along with nine known compounds (<b>2</b>-<b>10</b>), were isolated from the heartwood of <i>Cordia trichotoma</i>. Their structures were elucidated based on NMR spectroscopic data, and by comparison with data previously reported in literature. The hexane extract from the heartwood of <i>C. trichotoma</i>, the EtOH extract from the heartwood of <i>C. trichotoma</i>, the CH<sub>2</sub>Cl<sub>2</sub>-soluble fraction of the EtOH extract, the EtOAc-soluble fraction of the EtOH extract and the compounds <b>1</b>-<b>6</b> have been evaluated as acetylcholinesterase inhibitors, and among these, the extracts and fractions exhibited satisfactory results. In addition, compounds <b>5</b>, <b>7</b>, and <b>8</b> have not been reported previously from this genus.
Authors
- Francis M. Lopes (ORCID: https://orcid.org/0000-0001-9767-4463)
- M. Trevisan (ORCID: https://orcid.org/0000-0003-1274-7497)
- Otília Deusdênia Loiola Pessoa (ORCID: https://orcid.org/0000-0002-1617-7586)
- Francisco Mateus Gomes do Nascimento (ORCID: https://orcid.org/0000-0003-1790-3479)
- Horlando Carlota da Silva (ORCID: https://orcid.org/0000-0001-8996-6095)
- Gilvandete M. P. Santiago (ORCID: https://orcid.org/0000-0002-6832-8374)
- Francisco das Chagas Lima Pinto (ORCID: https://orcid.org/0000-0003-1481-7970)
Institutions
- Universidade Federal do Ceará (BR)
- University for International Integration of the Afro-Brazilian Lusophony (BR)
Publication Details
- Journal
- Natural Product Research
- Published
- 2024-12-24
- DOI
- https://doi.org/10.1080/14786419.2024.2444569
- Primary Topic
- Phytochemistry Medicinal Plant Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00