Hypoglycaemic stimulation of macrophage cytokine release is suppressed by <scp>AMP</scp>‐activated protein kinase activation
Taken together, these data indicate that pharmacological AMPK activation suppresses the release of MIF from macrophages caused by energy stress, suggesting that AMPK activation could be a useful strategy for mitigating hypoglycaemia-induced inflammation.
Authors
- David Carling (ORCID: https://orcid.org/0000-0002-2316-1830)
- Alice Pollard
- Benoı̂t Viollet (ORCID: https://orcid.org/0000-0002-0121-0224)
- Kate L. J. Ellacott (ORCID: https://orcid.org/0000-0001-5261-7465)
- Craig Beall (ORCID: https://orcid.org/0000-0002-4263-0866)
- Ewan R. Pearson (ORCID: https://orcid.org/0000-0001-9237-8585)
- Jiping Zhang
Institutions
- Centre National de la Recherche Scientifique (FR)
- Inserm (FR)
- Université Paris Cité (FR)
- University of Exeter (GB)
- Hammersmith Hospital (GB)
- Institut Cochin (FR)
- MRC London Institute of Medical Sciences (GB)
- Imperial College London (GB)
Publication Details
- Journal
- Diabetic Medicine
- Published
- 2024-12-24
- DOI
- https://doi.org/10.1111/dme.15456
- Citations
- 1
- Primary Topic
- Macrophage Migration Inhibitory Factor
- Type
- article
- Field-Weighted Citation Impact
- 0.24
Funders
- AstraZeneca
- Diabetes UK
- Medical Research Council
- Biotechnology and Biological Sciences Research Council