Donor C1 Group KIR-ligand inferiority is linked to increased mortality in haploidentical hematopoietic stem cell transplantation with post-transplant cyclophosphamide

These findings suggest an increased risk for NRM, particularly infection-related deaths, associated with C1-inferior donors. Upon independent confirmation, C1-inferior donors should be avoided in PTCy-based haploidentical HSCT.

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Publication Details

Journal
Cytotherapy
Published
2024-12-24
DOI
https://doi.org/10.1016/j.jcyt.2024.12.003
Primary Topic
Hematopoietic Stem Cell Transplantation
Type
article
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article

Donor C1 Group KIR-ligand inferiority is linked to increased mortality in haploidentical hematopoietic stem cell transplantation with post-transplant cyclophosphamide

Alexander Nikoloudis, Thomas Bauer, Olga Stiefel, Sigrid Machherndl‐Spandl et al.
Cytotherapy
Hematopoietic Stem Cell Transplantation
article

Donor C1 Group KIR-ligand inferiority is linked to increased mortality in haploidentical hematopoietic stem cell transplantation with post-transplant cyclophosphamide

Alexander Nikoloudis, Thomas Bauer, Olga Stiefel, Sigrid Machherndl‐Spandl, Christoph Aichinger, Andreas Petzer, Emine Kaynak, Holger F. Rumpold, Veronika Buxhofer‐Ausch, Robert Milanov, Irene Straßl, Johannes Clausen, Dagmar Wipplinger, Ansgar Weltermann, Petra Hasengruber, Michaela Binder, Anna Bauhofer, Lena Griessl, Anke Habermehl, Christina Groiss
article en

Abstract

These findings suggest an increased risk for NRM, particularly infection-related deaths, associated with C1-inferior donors. Upon independent confirmation, C1-inferior donors should be avoided in PTCy-based haploidentical HSCT.

CytotherapyVol. 27(4)
Krankenhaus der Elisabethinen (AT)
Good health and well-being
Openalex Percentile: Top 56%
Hematopoietic Stem Cell Transplantation
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