Prevalence and Risk Factors for Atherosclerotic Cardiovascular Disease in 7704 Individuals: An Analysis from the Greek Registry for the Prevalence of Familial Hypercholesterolemia (GRegistry-FH)
The intention of this study was to profile the cohort from the Greek Registry for the prevalence of Familial Hypercholesterolemia (GRegistry-FH) by estimating the prevalence of coronary artery disease (CAD), myocardial infarction (MI), stroke, dyslipidemia, arterial hypertension, diabetes mellitus (DM), pre-DM, smoking, abnormal thyroid function (ATF), and lipid values. The GRegistry-FH is a prospective study involving door-to-door interviews conducted by trained interviewers. Overall, 7704 individuals aged ≥18 years, randomly selected from all the regions of Greece, participated. The prevalence of atherosclerotic cardiovascular disease (ASCVD) was 13.9% (CAD 6%, MI 3.2%, stroke 4.7%). Treated hypercholesterolemia was present in 20.1%, arterial hypertension in 24%, and DM in 11.3% individuals (25.5% had pre-DM). The prevalence of smoking was 37.9% (29% current) and the prevalence of ATF was 13.1% (hypothyroidism 11.3%). A family history of ASCVD was reported by 60.5% (CAD 32.2%, stroke 28.3%). The mean (SD) lipid values in mg/dL were as follows: total cholesterol of 201.8 (41.5), low-density lipoprotein cholesterol of 126.3 (30.1), high-density lipoprotein cholesterol of 51.9 (12.5), and triglycerides of 135.9 (64.7). The GRegistry-FH highlights the significant prevalence of ASCVD and its risk factors among Greek adults, indicating a pressing need for early detection and management strategies to mitigate ASCVD burden. This nationwide registry serves as a crucial tool for guiding public health policies and personalized preventive measures (NCT03140605).
Authors
- Christina Marvaki
- Charalambos Vlachopoulos (ORCID: https://orcid.org/0000-0002-9904-3558)
- Katerina Anagnostopoulou
- Petros Kalogeropoulos (ORCID: https://orcid.org/0000-0002-7708-5431)
- Vasiliki Giannakopoulou
- Vana Kolovou
- Genovefa Kolovou (ORCID: https://orcid.org/0000-0001-8788-4555)
- Aikaterini Marvaki
- Sotiria Limberi
- Haralampos J Milionis (ORCID: https://orcid.org/0000-0003-3958-2266)
- Stefanos Foussas
- Niki Katsiki (ORCID: https://orcid.org/0000-0003-0894-2644)
- Despina Perrea
- Stamatis S. Makrygiannis
- Όλγα Καδδά (ORCID: https://orcid.org/0000-0002-4717-3529)
- Niki Pavlatou
- Evangelos Liberopoulos (ORCID: https://orcid.org/0000-0002-7162-3323)
- Edison Jahaj (ORCID: https://orcid.org/0000-0002-7306-713X)
- G. Goumas (ORCID: https://orcid.org/0009-0008-5940-2043)
- Anastasios Tzenalis (ORCID: https://orcid.org/0000-0002-6853-8953)
- Αndreas Μelidonis (ORCID: https://orcid.org/0000-0003-0505-5708)
- Ioannis Tsolakoglou (ORCID: https://orcid.org/0009-0006-9461-1815)
- Helen Bilianou
- Zeimpek Emre
- Zoi Kasiara
- Ilias Giannakoulis
- Nikolaos Tsaloukidis (ORCID: https://orcid.org/0000-0002-4003-1739)
- Rafailia Koulaxidou
- Giannis Hoursalas
Institutions
- University of Patras (GR)
- International Hellenic University (GR)
- University of Ioannina (GR)
- National and Kapodistrian University of Athens (GR)
- European University Cyprus (CY)
- Aristotle University of Thessaloniki (GR)
- Agios Pavlos General Hospital (GR)
- University of West Attica (GR)
- Laiko General Hospital of Athens (GR)
- Onassis Cardiac Surgery Center (GR)
- Hygeia Hospital (GR)
- Tzaneion General Hospital (GR)
- Athens Medical Center (GR)
- University General Hospital Attikon (GR)
- Metropolitan Hospital (GR)
- Athens Euroclinic (GR)
- Argo (Greece) (GR)
- Evangelismos Hospital (GR)
- Sotiria General Hospital (GR)
Publication Details
- Journal
- Journal of Cardiovascular Development and Disease
- Published
- 2024-12-23
- DOI
- https://doi.org/10.3390/jcdd11120411
- Citations
- 4
- Primary Topic
- Lipoproteins and Cardiovascular Health
- Type
- article
- Field-Weighted Citation Impact
- 2.29