Spatial Genomics Identifies Heat Shock Proteins as Key Molecular Changes Associated to Adipose Periprostatic Space Invasion in Prostate Cancer
PCa invasion of adipose EPE induces adaptative process related to heat shock proteins; PCa cells in EPE also present transcriptomics signatures for ERG independent aggressiveness, androgen receptor co-activation, and specific CNV changes.
Authors
- Julien Lavergne
- Géraldine Cancel‐Tassin (ORCID: https://orcid.org/0000-0002-9583-6382)
- F. Bruyère (ORCID: https://orcid.org/0000-0002-9281-9421)
- Olivier Cussenot (ORCID: https://orcid.org/0000-0002-9912-0533)
- Gaëlle Fromont (ORCID: https://orcid.org/0000-0002-7730-2264)
- Alix Fontaine (ORCID: https://orcid.org/0000-0002-2810-8799)
- Coralie Mousset
- Lucie Poupel (ORCID: https://orcid.org/0000-0001-7015-8450)
Institutions
- Université de Tours (FR)
- Université d'Orléans (FR)
- Inserm (FR)
- University of Oxford (GB)
- Centre de Recherche des Cordeliers (FR)
- Clinical Investigation Center Plurithematic Tours (FR)
- Medical University of Vienna (AT)
Publication Details
- Journal
- Cancers
- Published
- 2024-12-24
- DOI
- https://doi.org/10.3390/cancers17010002
- Citations
- 4
- Primary Topic
- Heat shock proteins research
- Type
- article
- Field-Weighted Citation Impact
- 0.94