Directed stochasticity: Building biomolecular condensates in the right place
Controlling biomolecular condensate formation within the nucleus is critical for genome function. In this issue, Xu et al. (https://doi.org/10.1083/jcb.202401036) report that KPNA3 promotes histone locus body formation and expression of replication-dependent histone genes by both importing NPAT into the nucleus and preventing NPAT condensation from improperly occurring in the cytoplasm.
Authors
- Robert J. Duronio (ORCID: https://orcid.org/0000-0001-6469-6965)
- James P. Kemp (ORCID: https://orcid.org/0000-0003-1975-1149)
- Mark S. Geisler (ORCID: https://orcid.org/0000-0002-2900-4609)
Institutions
- University of North Carolina at Chapel Hill (US)
Publication Details
- Journal
- The Journal of Cell Biology
- Published
- 2024-12-24
- DOI
- https://doi.org/10.1083/jcb.202412035
- Citations
- 2
- Primary Topic
- Genomics and Chromatin Dynamics
- Type
- article
- Field-Weighted Citation Impact
- 0.47