Porous Nanocomposite Implants With Gold Nanoparticles for Plastic Surgery
This study presents an innovative approach to improve implant biointegration and reduce implant-associated infections using porous poly(vinyl formal) nanocomposite matrices incorporated with gold nanoparticles and antimicrobial/anticancer drugs for plastic surgery applications. The porous matrices were characterized using physicochemical techniques and in vitro biochemical assays. The results demonstrated the biocompatibility of PVF nanocomposites and their potential for functionalization with various bioactive molecules and drugs, thereby enhancing their therapeutic efficacy. In vivo studies in rabbits revealed progressive replacement of implants with fibrous tissue, indicating successful biointegration with the surrounding soft tissues. Future research will focus on the long-term biocompatibility and functionalization of these nanocomposite implants for plastic surgery and explore their potential in other biomedical applications such as wound healing, tissue engineering, and scaffolds for cell growth and differentiation.
Authors
- V. I. Podolska (ORCID: https://orcid.org/0000-0003-3897-2860)
- Liudmyla Kernosenko (ORCID: https://orcid.org/0000-0001-6463-9098)
- Tetiana Poltoratska (ORCID: https://orcid.org/0000-0001-5900-2578)
- Olena Korotych (ORCID: https://orcid.org/0000-0002-0835-2305)
- Т. Г. Грузина (ORCID: https://orcid.org/0000-0002-7613-7391)
- Yu. M. Samchenko (ORCID: https://orcid.org/0000-0002-0011-3254)
- Natalia Pasmurtseva (ORCID: https://orcid.org/0000-0002-1403-0513)
- S. М. Dybkova (ORCID: https://orcid.org/0000-0002-8580-2584)
- Л. С. Рєзніченко (ORCID: https://orcid.org/0000-0002-3652-4426)
- Oleksandr Artiomov
- A. Maletskyi
- Pavlo Vorotytskiy
Institutions
- National Academy of Sciences of Ukraine (UA)
- F.D. Ovcharenko Institute of Biocolloidal Chemistry (UA)
- Filatov Institute of Eye Diseases and Tissue Therapy of the National Academy of Medical Sciences of Ukraine (UA)
- University of Tennessee at Knoxville (US)
Publication Details
- Journal
- Journal of Biomedical Materials Research Part A
- Published
- 2024-12-24
- DOI
- https://doi.org/10.1002/jbm.a.37851
- Citations
- 1
- Primary Topic
- Bone Tissue Engineering Materials
- Type
- article
- Field-Weighted Citation Impact
- 0.18
Funders
- National Research Foundation of Ukraine