Feed additives for methane mitigation: A guideline to uncover the mode of action of antimethanogenic feed additives for ruminants
This publication aims to provide guidelines of the knowledge required and the potential research to be conducted in order to understand the mode of action of antimethanogenic feed additives (AMFA). In the first part of the paper, we classify AMFA into 4 categories according to their mode of action: (1) lowering dihydrogen (H<sub>2</sub>) production; (2) inhibiting methanogens; (3) promoting alternative H<sub>2</sub>-incorporating pathways; and (4) oxidizing methane (CH<sub>4</sub>). The second part of the paper presents questions that guide the research to identify the mode of action of an AMFA on the rumen CH<sub>4</sub> production from 5 different perspectives: (1) microbiology; (2) cell and molecular biochemistry; (3) microbial ecology; (4) animal metabolism; and (5) cross-cutting aspects. Recommendations are provided to address various research questions within each perspective, along with examples of how aspects of the mode of action of AMFA have been elucidated before. In summary, this paper offers timely and comprehensive guidelines to better understand and reveal the mode of action of current and emerging AMFA.
Authors
- Fernanda G. Santos (ORCID: https://orcid.org/0000-0002-6556-5147)
- Jeyamalar Jeyanathan
- Peter Lund (ORCID: https://orcid.org/0000-0002-9113-4500)
- Stefan Muetzel (ORCID: https://orcid.org/0000-0003-4856-3497)
- Diego Morgavi (ORCID: https://orcid.org/0000-0002-3883-0937)
- Tim Angus McAllister (ORCID: https://orcid.org/0000-0002-8266-6513)
- Emilio M. Ungerfeld (ORCID: https://orcid.org/0000-0002-5422-5462)
- A. Bannink
- Z. Durmic (ORCID: https://orcid.org/0000-0001-7300-043X)
- Alejandro Belanche (ORCID: https://orcid.org/0000-0001-5880-6021)
- Roderick Ian Mackie (ORCID: https://orcid.org/0000-0002-4767-9300)
- Sharon Huws (ORCID: https://orcid.org/0000-0002-9284-2453)
- David R. Yáñez-Ruíz (ORCID: https://orcid.org/0000-0003-4397-3905)
- Dipti Pitta (ORCID: https://orcid.org/0000-0002-3102-9119)
- J. Dijkstra (ORCID: https://orcid.org/0000-0003-3728-6885)
- F. Javier Giráldez García (ORCID: https://orcid.org/0000-0002-0748-9692)
Institutions
- Queen's University Belfast (GB)
- Agriculture and Agri-Food Canada (CA)
- University of Illinois Urbana-Champaign (US)
- Universidad Nacional de Córdoba (AR)
- The University of Western Australia (AU)
- Université Clermont Auvergne (FR)
- Aarhus University (DK)
- Universidad de Zaragoza (ES)
- Genesis HealthCare (US)
- Ghent University (BE)
- AgResearch (NZ)
- Instituto de Investigaciones Agropecuarias (CL)
- Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement (FR)
- Estación Experimental del Zaidín (ES)
- VetAgro Sup (FR)
- Wageningen University & Research (NL)
Publication Details
- Journal
- Journal of Dairy Science
- Published
- 2024-12-24
- DOI
- https://doi.org/10.3168/jds.2024-25046
- Citations
- 29
- Primary Topic
- Ruminant Nutrition and Digestive Physiology
- Type
- article
- Field-Weighted Citation Impact
- 16.46