Network-wide effects of pallidal deep brain stimulation normalised abnormal cerebellar cortical activity in the dystonic animal model
These findings suggest that pallidal DBS exerts some of its therapeutic effects on dystonia by normalising neuronal activity within the cerebellar cortex. Our findings of reduced MFR and spike amplitudes in the dt<sup>sz</sup> hamsters could be a hint of a decrease in neuronal fibres and synaptic plasticity. Treatment with pallidal DBS led to cerebellar cortical activity similar to healthy controls, displaying the network-wide impact of local stimulation.
Authors
- Henning Bathel
- Rüdiger Köhling (ORCID: https://orcid.org/0000-0003-3330-4898)
- Jens Starke (ORCID: https://orcid.org/0000-0001-9411-5893)
- Konstantinos Spiliotis (ORCID: https://orcid.org/0000-0002-5651-5631)
- Tina Sellmann
- Fabiana Santana Kragelund
- Anika Lüttig (ORCID: https://orcid.org/0009-0006-7638-978X)
- Marco Heerdegen (ORCID: https://orcid.org/0000-0002-6320-441X)
- Denise Franz (ORCID: https://orcid.org/0000-0002-1877-3058)
- Angelika Richter
Institutions
- University of Rostock (DE)
Publication Details
- Journal
- Neurobiology of Disease
- Published
- 2024-12-24
- DOI
- https://doi.org/10.1016/j.nbd.2024.106779
- Citations
- 6
- Primary Topic
- Neurological disorders and treatments
- Type
- article
- Field-Weighted Citation Impact
- 2.21
Funders
- Deutsche Forschungsgemeinschaft