Pericytes and Extracellular Vesicle Interactions in Neurovascular Adaptation to Chronic Arterial Hypertension
Our findings demonstrate that cerebral pericytes undergo phenotypic and metabolic reprogramming in response to hypertension, with hypertensive-derived plasma-derived extracellular vesicles impairing their mitochondrial function. Importantly, plasma-derived extracellular vesicles from normotensive controls restore this function, suggesting their potential as both therapeutic agents and precision biomarkers for hypertensive vascular complications. Further investigation into plasma-derived extracellular vesicle cargo is essential to further explore their therapeutic potential in vascular health.
Authors
- Ildikò Rita Dunay (ORCID: https://orcid.org/0000-0002-9900-8605)
- Alejandra P. Garza (ORCID: https://orcid.org/0000-0002-2993-7679)
- Lorena Morton (ORCID: https://orcid.org/0000-0002-3957-3848)
- Sven Guenther Meuth (ORCID: https://orcid.org/0000-0003-2571-3501)
- Philipp Arndt (ORCID: https://orcid.org/0000-0002-0517-6473)
- Grażyna Dębska–Vielhaber (ORCID: https://orcid.org/0000-0002-6661-9821)
- Stefanie Schreiber (ORCID: https://orcid.org/0000-0003-4439-4374)
- Solveig Henneicke (ORCID: https://orcid.org/0000-0002-9103-7276)
- Luis E. Villafuerte (ORCID: https://orcid.org/0009-0003-2930-2635)
Institutions
- German Center for Neurodegenerative Diseases (DE)
- Center for Behavioral Brain Sciences (DE)
- Heinrich Heine University Düsseldorf (DE)
- Otto-von-Guericke-Universität Magdeburg (DE)
Publication Details
- Journal
- Journal of the American Heart Association
- Published
- 2024-12-25
- DOI
- https://doi.org/10.1161/jaha.124.038457
- Citations
- 6
- Primary Topic
- Barrier Structure and Function Studies
- Type
- article
- Field-Weighted Citation Impact
- 1.48