Recommendations for reporting and evaluating proton therapy beyond dose and constant relative biological effectiveness
A constant RBE of 1.1 was the consensus for prescribing dose. However, current practice of recording and reporting dose in proton therapy must be complemented: the recommended quantity beyond dose was the dose-averaged LET in water from primary and secondary protons, normalized to unit density. This will facilitate analyses of treatment data on effectiveness beyond dose and between centres. No consensus on a single variable RBE model was found. More clinical training on proton RBE is needed.
Authors
- Semi Harrabi (ORCID: https://orcid.org/0000-0003-1195-7150)
- Ana Vaniqui (ORCID: https://orcid.org/0000-0003-0530-1294)
- Armin Lühr (ORCID: https://orcid.org/0000-0002-9450-6859)
- Lars Glimelius (ORCID: https://orcid.org/0000-0002-9112-891X)
- Miranda C.A. Kramer (ORCID: https://orcid.org/0009-0003-5040-998X)
- Steven Habraken (ORCID: https://orcid.org/0000-0001-9986-886X)
- Daniëlle B. P. Eekers (ORCID: https://orcid.org/0000-0003-1917-6279)
- Ranald I. Mackay (ORCID: https://orcid.org/0000-0002-7329-6127)
- Alexandru Daşu (ORCID: https://orcid.org/0000-0001-8171-2541)
- Damien C. Weber (ORCID: https://orcid.org/0000-0003-1166-8236)
- Dirk Wagenaar (ORCID: https://orcid.org/0000-0001-8321-6824)
Institutions
- Uppsala University (SE)
- University Medical Center Groningen (NL)
- University of Groningen (NL)
- TU Dortmund University (DE)
- Heidelberg University (DE)
- Leiden University Medical Center (NL)
- Maastricht University Medical Centre (NL)
- University Hospital Heidelberg (DE)
- Paul Scherrer Institute (CH)
- University of Manchester (GB)
- Heidelberger Institut für Radioonkologie (DE)
- Belgian Nuclear Research Centre (BE)
- The Christie NHS Foundation Trust (GB)
- RaySearch Laboratories (Sweden) (SE)
- Maastro Clinic (NL)
Publication Details
- Journal
- Physics and Imaging in Radiation Oncology
- Published
- 2024-12-25
- DOI
- https://doi.org/10.1016/j.phro.2024.100692
- Citations
- 9
- Primary Topic
- Radiation Therapy and Dosimetry
- Type
- article
- Field-Weighted Citation Impact
- 3.77