Extracellular Mitochondria Exacerbate Retinal Pigment Epithelium Degeneration in Diabetic Retinopathy
A therapeutic strategy for retinal pigment epithelium degeneration should be developed in diabetic retinopathy. We investigated the molecular mechanisms underpinning retinal pigment epithelium degeneration by extracellular mitochondria in diabetic retinopathy. Extracellular mitochondria were found in the vitreous humor of patients with diabetic retinopathy and exacerbated retinal pigment epithelium degeneration through DNA-dependent protein kinase, cytokine expression via Toll-like receptor 9, and macrophage activation. Extracellular mitochondria are designated as an aggravating factor of neurodegeneration and inflammation in diabetic retinopathy.
Authors
- Noriko Terada (ORCID: https://orcid.org/0000-0003-2691-5754)
- Tomoaki Murakami (ORCID: https://orcid.org/0000-0002-0314-8807)
- Miyo Yoshida (ORCID: https://orcid.org/0000-0002-8599-9516)
- Keiichi Nishikawa
- Akitaka Tsujikawa (ORCID: https://orcid.org/0000-0003-0779-7799)
- Kenji Ishihara (ORCID: https://orcid.org/0000-0002-4153-6659)
- Yuki Mori (ORCID: https://orcid.org/0000-0003-0015-9188)
- Shinji Ito
Institutions
- Kyoto University (JP)
Publication Details
- Journal
- Diabetes
- Published
- 2024-12-23
- DOI
- https://doi.org/10.2337/db24-0040
- Citations
- 6
- Primary Topic
- Retinal Diseases and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 3.23