A cell-based model to study mechanisms of endothelial-dependent thrombin generation in response to inflammation and its modulation by hydroxychloroquine
We provide detailed optimization of a robust <i>in vitro</i> model to assess the induction of an inflammation-driven endothelial prothrombotic phenotype that is also sensitive to immunomodulatory therapies, providing a tool for investigating mechanisms of disease and new drugs.
Authors
- Anna M. Randi
- Golzar Mobayen (ORCID: https://orcid.org/0009-0007-3847-5035)
- Michael Laffan (ORCID: https://orcid.org/0000-0002-8268-3268)
- Josefin Ahnström (ORCID: https://orcid.org/0000-0001-5313-6508)
- Deepa J. Arachchillage (ORCID: https://orcid.org/0000-0001-5993-4850)
- Charis Pericleous (ORCID: https://orcid.org/0000-0001-8804-0493)
Institutions
- Imperial College Healthcare NHS Trust (GB)
- Imperial College London (GB)
Publication Details
- Journal
- Research and Practice in Thrombosis and Haemostasis
- Published
- 2024-12-24
- DOI
- https://doi.org/10.1016/j.rpth.2024.102665
- Citations
- 4
- Primary Topic
- Blood Coagulation and Thrombosis Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 1.82
Funders
- Wellcome Trust
- National Institute for Health and Care Research
- Imperial College London
- Versus Arthritis
- Medical Research Council
- NIHR Imperial Biomedical Research Centre