Diacylglycerol Kinase ζ Attenuates Doxorubicin‐Induced Cardiotoxicity Through p53 Degradation
We demonstrated for the first time that Dgkζ augments p53 ubiquitin-proteasome degradation and ameliorates doxorubicin-induced cardiotoxicity by interacting with Hsp70 and E3 ligases such as E6ap and C-terminus of Hsp70-interacting protein.
Authors
- Haruki Ochi (ORCID: https://orcid.org/0000-0002-0088-581X)
- Toshiaki Tanaka (ORCID: https://orcid.org/0000-0003-1329-838X)
- Hiroki Takahashi (ORCID: https://orcid.org/0000-0003-0528-0446)
- Kaoru Goto (ORCID: https://orcid.org/0000-0001-5733-2864)
- Masafumi Watanabe
- Ryutaro Yamaguchi
- Yoichiro Otaki (ORCID: https://orcid.org/0000-0001-7859-1427)
- Junya Sato
- Shingo Tachibana (ORCID: https://orcid.org/0009-0004-6368-6510)
- Takanori Arimoto (ORCID: https://orcid.org/0000-0003-2802-0794)
- Hiroe Ono
- Tetsu Watanabe (ORCID: https://orcid.org/0000-0002-4565-3799)
- Jun Goto (ORCID: https://orcid.org/0009-0008-9113-5969)
Institutions
- Yamagata University (JP)
Publication Details
- Journal
- Journal of the American Heart Association
- Published
- 2024-12-25
- DOI
- https://doi.org/10.1161/jaha.124.035608
- Citations
- 5
- Primary Topic
- Chemotherapy-induced cardiotoxicity and mitigation
- Type
- article
- Field-Weighted Citation Impact
- 2.01
Funders
- Ministry of Education, Culture, Sports, Science and Technology