Single Cell Transcriptomic Profiling of <i>MYBPC3</i> ‐Associated Hypertrophic Cardiomyopathy Across Species Reveals Conservation of Biological Process But Not Gene Expression
These common biological processes across species are consistent with known phenotypic aspects of HCM such as hypertrophy, hypercontractility, diastolic dysfunction, and altered energy metabolism. Surprisingly, among conserved biological processes within cardiomyocytes across species, the individual genes driving the biological processes were distinct. This work to identify common and species-specific disease-promoting pathway differences will allow development of targeted therapies for both human and veterinary application and will facilitate an understanding of the idiosyncrasies of mouse models.
Authors
- Michael T. Chin (ORCID: https://orcid.org/0000-0003-3065-8498)
- J E Laird (ORCID: https://orcid.org/0000-0003-4725-7420)
- Gayani Perera (ORCID: https://orcid.org/0009-0002-2898-9239)
- Martin S. Maron (ORCID: https://orcid.org/0000-0002-9923-3853)
- Victor N. Rivas (ORCID: https://orcid.org/0000-0002-5016-3743)
- Rebecca Batorsky (ORCID: https://orcid.org/0000-0003-4712-6500)
- Joshua A. Stern (ORCID: https://orcid.org/0000-0001-5611-5745)
- Samantha P. Harris (ORCID: https://orcid.org/0000-0003-0822-0238)
- Samia Ali
Institutions
- Tufts University (US)
- Lahey Hospital and Medical Center (US)
- Tufts Medical Center (US)
- North Carolina State University (US)
- University of Arizona (US)
- Johns Hopkins University (US)
Publication Details
- Journal
- Journal of the American Heart Association
- Published
- 2024-12-25
- DOI
- https://doi.org/10.1161/jaha.124.035780
- Citations
- 5
- Primary Topic
- Cardiomyopathy and Myosin Studies
- Type
- article
- Field-Weighted Citation Impact
- 2.01