Modulation of Abnormal Vasoconstriction Through 2‐Hydroxyisobutyrylation of Tropomyosin 3 Lys141: Targeting Histone Deacetylase 3 as a Key Approach
These findings underscore the critical role of TPM3 de-2-hydroxyisobutyrylation in vasoconstriction and suggest that modulating this posttranslational modification could provide a novel therapeutic strategy for hypertensive vascular dysfunction.
Authors
- Guanrong Qiao
- Pan‐Pan Pang
- Yong‐Tang Zheng (ORCID: https://orcid.org/0000-0001-5469-0324)
- Wenbin Su (ORCID: https://orcid.org/0000-0002-4546-9051)
- Chang‐Bo Zheng (ORCID: https://orcid.org/0000-0001-6981-0210)
- Wen‐Cong Gao (ORCID: https://orcid.org/0000-0002-8427-4273)
- Jing Yuan (ORCID: https://orcid.org/0000-0002-6992-969X)
- Jiangxin Liu (ORCID: https://orcid.org/0000-0002-8468-1434)
Institutions
- Kunming Institute of Botany (CN)
- Kunming Institute of Zoology (CN)
- Chinese Academy of Sciences (CN)
- Kunming Medical University (CN)
- University of Hong Kong (HK)
Publication Details
- Journal
- Journal of the American Heart Association
- Published
- 2024-12-25
- DOI
- https://doi.org/10.1161/jaha.124.037400
- Primary Topic
- Histone Deacetylase Inhibitors Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Kunming Medical University
- Yunnan Provincial Science and Technology Department
- Yunnan Key Research and Development Program