Generation of an induced pluripotent stem cell (iPSC) line (INNDSUi007-A) from a patient with Kennedy disease
Abnormal trinucleotide CAG repeat expansions in exon 1 of the Androgen Receptor (AR) gene has been identified as the cause of Kennedy disease (KD). We generated and characterized a human induced pluripotent stem cell (iPSC) line from peripheral blood mononuclear cells (PBMC) of a patient with genetically confirmed KD. The pluripotency of these iPSCs was verified by the expression of several pluripotency markers at both RNA and protein levels, as well as their capability to differentiate into all three germ layers.
Authors
- Xinbo Ji
- Xiaohan Sun
- Hongxu Wang (ORCID: https://orcid.org/0000-0001-5248-4578)
- Bo Kong
- Ping Sun (ORCID: https://orcid.org/0000-0002-1466-863X)
- Bo Gao (ORCID: https://orcid.org/0000-0002-4029-1258)
- Bo Li (ORCID: https://orcid.org/0000-0003-0668-1620)
- Jianing Li (ORCID: https://orcid.org/0000-0002-8999-9310)
- Yingxin Wang (ORCID: https://orcid.org/0000-0001-9032-9990)
- Fuchen Liu
- Yitong Yang (ORCID: https://orcid.org/0009-0007-2601-2420)
- Yao Tang
- Didi Shan
- Zexin Zhan
- Yichang Jiao (ORCID: https://orcid.org/0009-0004-2703-1912)
- Yu Wang (ORCID: https://orcid.org/0009-0005-0661-311X)
Institutions
- Shandong University (CN)
- Qilu Hospital of Shandong University (CN)
- Affiliated Hospital of Jining Medical University (CN)
- Shandong Academy of Chinese Medicine (CN)
- Jining Medical University (CN)
Publication Details
- Journal
- Stem Cell Research
- Published
- 2024-12-25
- DOI
- https://doi.org/10.1016/j.scr.2024.103638
- Primary Topic
- Genetic Neurodegenerative Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00