O-antigen of uropathogenic Escherichia coli is required for induction of neutrophil extracellular traps
Our results demonstrate that CFT073 LPS is essential for inducing ROS-dependent NETs and IL-1β secretion from neutrophils. This study also provides evidence for the crucial roles of O-antigen in the immune response to UPEC infection, as well as its potential as a therapeutic target for the treatment of UTIs.
Authors
- Kai Yu (ORCID: https://orcid.org/0000-0002-5453-8725)
- Hui‐Ching Cheng (ORCID: https://orcid.org/0000-0002-4732-602X)
- Ching‐Hao Teng (ORCID: https://orcid.org/0000-0002-4615-094X)
- Shew‐Meei Sheu (ORCID: https://orcid.org/0000-0001-5689-0928)
- Wei‐Hung Lin (ORCID: https://orcid.org/0000-0003-3690-627X)
- Cheng‐Yen Kao (ORCID: https://orcid.org/0000-0001-8782-3912)
- Li‐Jin Hsu (ORCID: https://orcid.org/0009-0007-9395-6077)
- Ming-Cheng Wang (ORCID: https://orcid.org/0000-0003-1668-9319)
- Ching‐Fang Wu (ORCID: https://orcid.org/0000-0002-3913-7587)
- Jiunn-Jong Wu
- Wen-Chun Huang
Institutions
- Asia University (TW)
- National Yang Ming Chiao Tung University (TW)
- E-Da Hospital (TW)
- Chia-Yi Christian Hospital (TW)
- National Cheng Kung University Hospital (TW)
- National Cheng Kung University (TW)
- National Yang Ming Chiao Tung University (TW)
Publication Details
- Journal
- Journal of Microbiology Immunology and Infection
- Published
- 2024-12-25
- DOI
- https://doi.org/10.1016/j.jmii.2024.12.007
- Citations
- 5
- Primary Topic
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 1.20
Funders
- Ministry of Science and Technology, Taiwan
- National Cheng Kung University Hospital