Targeting APJ drives BNIP3-PINK1-PARKIN induced mitophagy and improves systemic inflammatory bone loss
This study elucidated the underlying mechanism by which APJ modulates macrophage polarization, thereby proposing a new therapeutic target for addressing inflammatory bone loss.
Authors
- Jiaxiang Bai (ORCID: https://orcid.org/0000-0002-3485-5563)
- Dechun Geng (ORCID: https://orcid.org/0000-0003-4375-2803)
- Huilin Yang (ORCID: https://orcid.org/0000-0003-4637-5177)
- Ning Li (ORCID: https://orcid.org/0000-0002-6518-2541)
- Wei Wang (ORCID: https://orcid.org/0000-0002-9485-583X)
- Wentao Wang (ORCID: https://orcid.org/0000-0001-9919-7488)
- Qing Wang (ORCID: https://orcid.org/0009-0003-7328-8762)
- Hao Xu (ORCID: https://orcid.org/0000-0002-2767-3665)
- Yaozeng Xu (ORCID: https://orcid.org/0000-0002-0424-4884)
- Wenming Li (ORCID: https://orcid.org/0000-0002-7638-9978)
- Xiaolong Liang (ORCID: https://orcid.org/0009-0006-2618-791X)
- Shuli Yang (ORCID: https://orcid.org/0009-0006-3487-7582)
Institutions
- University of Science and Technology of China (CN)
- Soochow University (CN)
- Suzhou Vocational Health College (CN)
- First Affiliated Hospital of Soochow University (CN)
Publication Details
- Journal
- Journal of Advanced Research
- Published
- 2024-12-24
- DOI
- https://doi.org/10.1016/j.jare.2024.12.033
- Citations
- 5
- Primary Topic
- Autophagy in Disease and Therapy
- Type
- article
- Field-Weighted Citation Impact
- 1.93
Funders
- National Natural Science Foundation of China
- Government of Jiangsu Province
- Ministry of Education, India
- Priority Academic Program Development of Jiangsu Higher Education Institutions
- National Postdoctoral Program for Innovative Talents