Novel allelic variants of blaOXA-48-like carried on IncN2 and IncC2 plasmids isolated from clinical cases in Argentina: In vivo emergence of blaOXA-567
Both isolates were found to be resistant to carbapenems and susceptible to ceftriaxone. bla<sub>OXA-438</sub> was located on a 69-kb IncN<sub>2</sub> plasmid, while bla<sub>OXA-567</sub> was found on a 175-Kb IncC<sub>2</sub> plasmid, both transferable by biparental conjugation. The close genetic environment of the bla<sub>OXA</sub> genes suggests a common origin likely involving mobile genetic elements. Finally, the clinical case of M21014 revealed that the patient had previous infections with two genetically related K. pneumoniae ST6838 that carried bla<sub>OXA-163</sub> on an IncC<sub>2</sub> plasmid with equal size and genetic hallmarks to that of M21014, providing strong evidence for the intra-patient emergence of bla<sub>OXA-567.</sub> CONCLUSIONS: This research underscores the need for ongoing surveillance and integral studies to understand the emergence, biochemistry and dissemination capacity of OXA enzymes with the overarching aim to halt their spread.
Authors
- Fernando Pasterán (ORCID: https://orcid.org/0000-0001-5840-5869)
- Alejandra Corso (ORCID: https://orcid.org/0000-0003-1183-6746)
- Melina Rapoport (ORCID: https://orcid.org/0000-0001-6961-640X)
- Nathalie Tijet
- Bárbara Ghiglione (ORCID: https://orcid.org/0000-0002-1723-5135)
- P.P. Power (ORCID: https://orcid.org/0000-0002-7051-9954)
- E. Biondi
- Denise De Belder (ORCID: https://orcid.org/0000-0002-5568-4804)
- Juan Manuel de Mendieta
- Roberto G. Melano (ORCID: https://orcid.org/0000-0002-0268-1028)
- Adriana Di Bella
- Gomez A Sonia
Institutions
- Toronto Public Health (CA)
- Universidad de Buenos Aires (AR)
- Administración Nacional de Laboratorios e Institutos de Salud (AR)
- Public Health Ontario (CA)
- Hospital de Niños Superiora Sor María Ludovica (AR)
- Instituto de Química y Fisicoquímica Biológicas (AR)
- Hospital General de Niños Ricardo Gutierrez (AR)
Publication Details
- Journal
- Journal of Global Antimicrobial Resistance
- Published
- 2024-12-25
- DOI
- https://doi.org/10.1016/j.jgar.2024.12.008
- Citations
- 1
- Primary Topic
- Antibiotic Resistance in Bacteria
- Type
- article
- Field-Weighted Citation Impact
- 0.17
Funders
- Ministry of Health
- Agencia Nacional de Promoción Científica y Tecnológica
- Fondo para la Investigación Científica y Tecnológica