Direct arylation of <i>gem</i>-difluorostyrenes using <i>in situ</i> mechanochemically generated calcium-based heavy Grignard reagents
Calcium-based heavy Grignard reagents, prepared in situ through a mechanochemical method, reacted with gem -difluorostyrenes to afford thermodynamically less favorable ( E )-monofluorostilbenes with good to high stereoselectivity.
Authors
- Satoshi Maeda (ORCID: https://orcid.org/0000-0001-8822-1147)
- Pan Gao (ORCID: https://orcid.org/0000-0001-9305-6959)
- Hajime Ito (ORCID: https://orcid.org/0000-0003-3852-6721)
- Koji Kubota (ORCID: https://orcid.org/0000-0003-1522-291X)
- Julong Jiang (ORCID: https://orcid.org/0000-0002-2357-1127)
- Yamato Fukuzawa
- Xihong Wang (ORCID: https://orcid.org/0000-0002-8832-7037)
Institutions
- Hokkaido University of Science (JP)
- Hokkaido University (JP)
Publication Details
- Journal
- RSC Mechanochemistry
- Published
- 2024-12-25
- DOI
- https://doi.org/10.1039/d4mr00135d
- Citations
- 7
- Primary Topic
- Fluorine in Organic Chemistry
- Type
- article
- Field-Weighted Citation Impact
- 1.46
Funders
- Ministry of Education, Culture, Sports, Science and Technology
- Japan Society for the Promotion of Science
- Core Research for Evolutional Science and Technology