LINC01094 promotes gastric cancer through dual targeting of CDKN1A by directly binding RBMS2 and HDAC1
The LINC01094-miR-128-3p-RUNX1 feedback loop downregulates CDKN1A and promotes GC cooperatively with RBMS2 and HDAC1. Furthermore, Ro 5-3335 may hold promising therapeutic potential in the treatment of GC. Hence, our study found an oncogenic lncRNA, LINC01094, which could be a promising target for cancer treatment and diagnosis.
Authors
- Xinyi Zhou (ORCID: https://orcid.org/0000-0003-2319-6301)
- Li Hu (ORCID: https://orcid.org/0000-0002-7535-6453)
- Hongan Shao (ORCID: https://orcid.org/0009-0001-7674-5952)
- Bojian Fei (ORCID: https://orcid.org/0000-0002-3672-0216)
- Fei Zuo
- Guanhua Chen (ORCID: https://orcid.org/0000-0002-9314-2037)
- Cheng Gu (ORCID: https://orcid.org/0000-0002-6300-6579)
- Linmei Xiao
Institutions
- Ningbo University (CN)
- Jiangnan University (CN)
- Nanjing University of Chinese Medicine (CN)
- Sun Yat-sen University (CN)
- Nanjing General Hospital of Nanjing Military Command (CN)
- Wuxi Fourth People's Hospital (CN)
- The First Affiliated Hospital, Sun Yat-sen University (CN)
- Nanjing Second Hospital (CN)
- Jiangsu Province Hospital (CN)
- Nanjing Medical University (CN)
- Nanjing University (CN)
Publication Details
- Journal
- Biology Direct
- Published
- 2024-12-24
- DOI
- https://doi.org/10.1186/s13062-024-00582-y
- Citations
- 5
- Primary Topic
- Cancer-related molecular mechanisms research
- Type
- article
- Field-Weighted Citation Impact
- 1.43
Funders
- Nanjing Medical University
- Natural Science Foundation of Ningbo
- Medical Science and Technology Project of Zhejiang Province
- Science and Technology Program of Zhejiang Province