Anti-CD4 monoclonal antibody prevents chronic graft-versus-host disease in mice by inducing immune tolerance of CD8+ T cells and alleviating thymus injury
Our results indicate that anti-CD4 mAb therapy early post-HCT allows thymus recovery by inducing the immune tolerance of thymus infiltrated CD8<sup>+</sup> T cells, thereby alleviating thymic epithelial cells damage, preserving negative selection, and preserving long-term GVL effect at the same time.
Authors
- Gusheng Tang (ORCID: https://orcid.org/0000-0002-2682-0985)
- Yan Zhang (ORCID: https://orcid.org/0000-0002-4752-5432)
- Jianmin Yang (ORCID: https://orcid.org/0000-0002-6572-1541)
- Hui Cheng (ORCID: https://orcid.org/0000-0001-9154-9282)
- Ruiqi Li (ORCID: https://orcid.org/0000-0001-8839-5884)
- Jianmin Wang (ORCID: https://orcid.org/0000-0001-5678-8202)
- Ziwei Wang (ORCID: https://orcid.org/0000-0002-3237-1522)
- Weijia Fu (ORCID: https://orcid.org/0000-0001-7235-5853)
- Xiong Ni (ORCID: https://orcid.org/0009-0003-4925-1417)
Institutions
- Second Military Medical University (CN)
- Changhai Hospital (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2024-12-24
- DOI
- https://doi.org/10.3389/fimmu.2024.1460687
- Citations
- 1
- Primary Topic
- T-cell and B-cell Immunology
- Type
- article
- Field-Weighted Citation Impact
- 0.24
Funders
- Shanghai Municipal Health Commission
- National Natural Science Foundation of China
- Changhai Hospital of Shanghai