Chinese expert consensus on sequential surgery following conversion therapy based on combination of immune checkpoint inhibitors and antiangiogenic targeted drugs for advanced hepatocellular carcinoma (2024 edition)
Up to half of hepatocellular carcinoma (HCC) cases are diagnosed at an advanced stage, for which effective treatment options are lacking, resulting in a poor prognosis. Over the past few years, the combination of immune checkpoint inhibitors and anti-angiogenic targeted therapy has proven highly efficacious in treating advanced HCC, significantly extending patients' survival and providing a potential for sequential curative surgery. After sequential curative hepatectomy or liver transplantation following conversion therapy, patients can receive long-term survival benefits. In order to improve the long-term survival rate of the overall population with liver cancer and achieve the goal of a 15% increase in the overall 5-year survival rate outlined in the Healthy China 2030 blueprint, the Professional Committee for Prevention and Control of Hepatobiliary and Pancreatic Diseases of Chinese Preventive Medicine Association, Chinese Society of Liver Cancer, and the Liver Study Group of Surgery Committee of Beijing Medical Association organized in-depth discussions among relevant domestic experts in the field. These discussions focused on the latest progress since the release of the Chinese expert consensus on conversion therapy of immune checkpoint inhibitors combined antiangiogenic targeted drugs for advanced hepatocellular carcinoma (2021 Edition) and resulted in a new consensus on the modifications and supplements to related key points. This consensus aims to further guide clinical practice, standardize medical care, and promote the development of the discipline.
Authors
- Yongping Yang (ORCID: https://orcid.org/0000-0002-8468-8476)
- Yinbiao Cao
- Yajin Chen (ORCID: https://orcid.org/0000-0002-2419-6330)
- Zhiyong Huang
- Shuyang Sun (ORCID: https://orcid.org/0000-0001-6013-0614)
- Daobing Zeng (ORCID: https://orcid.org/0000-0001-9675-5659)
- Maoqiang Wang (ORCID: https://orcid.org/0000-0002-0299-5289)
- Jian Zhou
- Jianqiang Cai (ORCID: https://orcid.org/0000-0002-3426-4579)
- Lantian Tian (ORCID: https://orcid.org/0000-0001-6123-7800)
- Hui‐Chuan Sun (ORCID: https://orcid.org/0000-0003-3761-7058)
- Lianxin Liu (ORCID: https://orcid.org/0000-0002-3535-6467)
- Shouwang Cai
- Tao Peng (ORCID: https://orcid.org/0000-0001-6133-7078)
- Xing Cui (ORCID: https://orcid.org/0000-0002-2955-7721)
- Chengang Li (ORCID: https://orcid.org/0009-0009-4164-1959)
- Wanguang Zhang (ORCID: https://orcid.org/0000-0003-3184-9907)
- Jie Gao (ORCID: https://orcid.org/0000-0003-1075-3631)
- Zusen Wang (ORCID: https://orcid.org/0000-0002-6250-6264)
- Ziman Zhu (ORCID: https://orcid.org/0000-0002-6806-919X)
- Jing Yuan (ORCID: https://orcid.org/0000-0002-3923-925X)
- Chaoliu Dai (ORCID: https://orcid.org/0000-0002-5122-2792)
- Jingyu Cao (ORCID: https://orcid.org/0000-0003-0508-1279)
- Minggen Hu (ORCID: https://orcid.org/0000-0001-7933-7850)
- Weibao Ding
- Shunchang Jiao
- Qiu Qiu (ORCID: https://orcid.org/0000-0002-0381-1461)
- Wanqing Gu
- Xinyu Bi (ORCID: https://orcid.org/0000-0002-4011-0939)
- Haosheng Jin (ORCID: https://orcid.org/0000-0001-7554-7551)
- Tianqiang Song (ORCID: https://orcid.org/0000-0001-5979-5213)
- Nian-Xin Xia (ORCID: https://orcid.org/0009-0007-7841-6806)
- Xiaodong Tian (ORCID: https://orcid.org/0000-0002-0943-5161)
- Jinghai Song (ORCID: https://orcid.org/0000-0003-1798-3229)
- Shunda Du (ORCID: https://orcid.org/0000-0002-9357-3259)
- Jinxue Zhou (ORCID: https://orcid.org/0000-0002-1168-1396)
- Wenbing Sun (ORCID: https://orcid.org/0000-0001-8080-1841)
- Kaishan Tao (ORCID: https://orcid.org/0000-0002-8573-0445)
- Yongyi Zeng (ORCID: https://orcid.org/0000-0001-8823-698X)
- Guang Tan (ORCID: https://orcid.org/0000-0002-0658-8867)
- Yinying Lu (ORCID: https://orcid.org/0009-0009-6145-1976)
- Yinzhe Xu (ORCID: https://orcid.org/0000-0002-8027-4559)
- Fei Li (ORCID: https://orcid.org/0000-0003-2872-5313)
- Junning Cao (ORCID: https://orcid.org/0000-0002-3146-9413)
- Qinghua Meng (ORCID: https://orcid.org/0000-0002-5522-9852)
- J. Y. Liao (ORCID: https://orcid.org/0000-0001-8277-6133)
- Bin Liang (ORCID: https://orcid.org/0000-0002-8771-2646)
- Zhao-Hai Wang (ORCID: https://orcid.org/0000-0001-6349-0439)
- Haitao Zhao (ORCID: https://orcid.org/0000-0002-3444-8044)
- Wenbin Ji (ORCID: https://orcid.org/0000-0002-7667-9430)
- Chunyi Hao (ORCID: https://orcid.org/0000-0002-1233-1689)
- Dianrong Xiu (ORCID: https://orcid.org/0009-0003-8563-5207)
- Weibo Niu (ORCID: https://orcid.org/0000-0002-8395-3442)
- Dongdong Lin (ORCID: https://orcid.org/0000-0002-7525-7973)
- Zhenyu Zhu
- X Y Feng (ORCID: https://orcid.org/0000-0001-8826-6310)
- Shunli Shen (ORCID: https://orcid.org/0000-0002-3133-3508)
- Jialin Zhang
- Kui Wang (ORCID: https://orcid.org/0000-0002-4756-9267)
- Ze Zhang (ORCID: https://orcid.org/0000-0001-9854-5823)
- Xiaodong Wang (ORCID: https://orcid.org/0009-0006-9976-2866)
- Wentao Wang (ORCID: https://orcid.org/0000-0001-5190-3355)
- Kai Li (ORCID: https://orcid.org/0000-0002-1746-7913)
- Wenwen Zhang (ORCID: https://orcid.org/0000-0003-1285-3118)
- Zhiqiang Wang (ORCID: https://orcid.org/0000-0003-4222-2026)
- Jiangtao Li (ORCID: https://orcid.org/0000-0001-7538-2910)
- Peng Li (ORCID: https://orcid.org/0000-0002-5078-5091)
- Zhijun Wang (ORCID: https://orcid.org/0000-0002-7601-5714)
- Meng Zhang (ORCID: https://orcid.org/0000-0003-4935-4005)
- Xiaoping Chen (ORCID: https://orcid.org/0000-0001-8636-0493)
- Zhe Liu (ORCID: https://orcid.org/0000-0003-1846-8472)
- Guangming Li (ORCID: https://orcid.org/0000-0002-0281-8258)
- Hong Zhao (ORCID: https://orcid.org/0000-0002-8255-030X)
- Quanli Han (ORCID: https://orcid.org/0000-0002-7389-934X)
- Jianming Xu (ORCID: https://orcid.org/0000-0003-4467-6021)
- Ning Yang (ORCID: https://orcid.org/0000-0002-3096-5802)
- Wenheng Zheng (ORCID: https://orcid.org/0000-0002-6713-9897)
- Rong Liu (ORCID: https://orcid.org/0009-0005-1327-112X)
- Ren Lang (ORCID: https://orcid.org/0000-0001-8995-8749)
- Yinmo Yang (ORCID: https://orcid.org/0000-0002-6202-6535)
- Hongguang Wang (ORCID: https://orcid.org/0000-0002-7620-614X)
- Jia Fan (ORCID: https://orcid.org/0000-0003-3487-2328)
- Tianfu Wen (ORCID: https://orcid.org/0000-0003-1979-9775)
- Jun Liang (ORCID: https://orcid.org/0000-0001-8814-7143)
- Baocai Xing (ORCID: https://orcid.org/0000-0002-9908-8588)
- Jun Zhou (ORCID: https://orcid.org/0000-0003-0642-8676)
- Ming Kuang (ORCID: https://orcid.org/0009-0001-7754-7317)
- Jiayin Yang
- Shichun Lu (ORCID: https://orcid.org/0000-0002-6974-4695)
- Yuan Guo (ORCID: https://orcid.org/0000-0003-0590-4810)
- Yongwei Chen (ORCID: https://orcid.org/0000-0001-7643-978X)
- Huaizhi Wang (ORCID: https://orcid.org/0000-0002-5421-5176)
- Huiguo Ding
- Min Zhu (ORCID: https://orcid.org/0000-0001-6614-606X)
- Jushan Wu
- Haowen Tang
- Bingyang Hu
- Jiye Zhu (ORCID: https://orcid.org/0000-0001-5406-2715)
- Li Gong (ORCID: https://orcid.org/0000-0002-4103-9468)
- Liqun Wu (ORCID: https://orcid.org/0000-0002-9682-5802)
- Jizhou Wang (ORCID: https://orcid.org/0000-0002-6934-072X)
- Feng Duan
- Xiao Zhao
- Yufeng Yuan (ORCID: https://orcid.org/0009-0009-9794-4895)
- Xilin Du
- Ping Liang (ORCID: https://orcid.org/0000-0002-7640-2351)
- Tao Wan
- Binwei Duan (ORCID: https://orcid.org/0009-0007-0229-4216)
- Mao-Lin Yan (ORCID: https://orcid.org/0009-0003-5188-6796)
- Zhanbo Wang
- Zuojin Liu (ORCID: https://orcid.org/0000-0002-0775-0774)
- Keming Zhang (ORCID: https://orcid.org/0000-0001-8636-1728)
Institutions
- Qingdao University (CN)
- Hebei Medical University (CN)
- University of Science and Technology of China (CN)
- Fujian Medical University (CN)
- Shandong University of Traditional Chinese Medicine (CN)
- Army Medical University (CN)
- Sun Yat-sen University (CN)
- Chongqing University (CN)
- Guangxi Medical University (CN)
- Second Military Medical University (CN)
- Capital Medical University (CN)
- Dalian Medical University (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Peking University (CN)
- Sichuan University (CN)
- Fudan University (CN)
- Guangdong General Hospital (CN)
- Beijing Chao-Yang Hospital, Capital Medical University (CN)
- Peking Union Medical College Hospital (CN)
- Tianjin Medical University Cancer Institute and Hospital (CN)
- Chinese PLA General Hospital (CN)
- Wuhan University (CN)
- West China Hospital of Sichuan University (CN)
- Beijing Shijingshan Hospital (CN)
- Peking University Cancer Hospital (CN)
- Sun Yat-sen Memorial Hospital (CN)
- Second Affiliated Hospital of Chongqing Medical University (CN)
- First Affiliated Hospital of Liaoning Medical University (CN)
- Fourth Hospital of Hebei Medical University (CN)
- Beijing Chest Hospital (CN)
- Weifang People's Hospital (CN)
- Qinghai Red Cross Hospital (CN)
- Mengchao Hepatobiliary Hospital (CN)
- Affiliated Hospital of Qingdao University (CN)
- Zhongnan Hospital of Wuhan University (CN)
- Peking University People's Hospital (CN)
- First Affiliated Hospital of GuangXi Medical University (CN)
- Zhongshan Hospital (CN)
- The First Affiliated Hospital, Sun Yat-sen University (CN)
- Peking University First Hospital (CN)
- Southwest Hospital (CN)
- Peking University International Hospital (CN)
- Eastern Hepatobiliary Surgery Hospital (CN)
- First Hospital of China Medical University (CN)
- First Affiliated Hospital of Dalian Medical University (CN)
- Peking University Third Hospital (CN)
- Fujian Provincial Hospital (CN)
- Henan Cancer Hospital (CN)
- Guangdong Academy of Medical Sciences (CN)
- Beijing YouAn Hospital (CN)
- Ministry of Education (ET)
- Beijing Tsinghua Chang Gung Hospital (CN)
- Tang Du Hospital (CN)
- Second Affiliated Hospital of Zhejiang University (CN)
- Affiliated Hospital of Shandong University of Traditional Chinese Medicine (CN)
- Tongji Hospital (CN)
- Liaoning Cancer Hospital & Institute (CN)
- Qilu Hospital of Shandong University (CN)
- First People's Hospital of Chongqing (CN)
- Beijing Chaoyang Emergency Medical Center (CN)
- Deleted Institution
- Huazhong University of Science and Technology (CN)
- Hainan Medical University (CN)
- Chongqing Medical University (CN)
- China Medical University (CN)
- Air Force Medical University (CN)
Publication Details
- Journal
- BioScience Trends
- Published
- 2024-12-24
- DOI
- https://doi.org/10.5582/bst.2024.01394
- Citations
- 14
- Primary Topic
- Hepatocellular Carcinoma Treatment and Prognosis
- Type
- article
- Field-Weighted Citation Impact
- 5.17