Activated kynurenine pathway metabolism by YKL-40 establishes an inhibitory immune microenvironment and drives glioblastoma development
YKL-40 upregulates IDO1 or TDO2 to activate KP metabolism, and coordinates with Kyn to establish an inhibitory tumor immune microenvironment, leading to tumor immune evasion.
Authors
- Ziyi Wang (ORCID: https://orcid.org/0000-0003-0962-1922)
- Hui Chen (ORCID: https://orcid.org/0000-0002-2281-5935)
- Xuemei Zhang (ORCID: https://orcid.org/0000-0002-0326-9262)
- Yingbin Liu (ORCID: https://orcid.org/0000-0001-6110-0185)
- Jing Luo (ORCID: https://orcid.org/0000-0002-1523-4665)
- Rhong-Guang Shao (ORCID: https://orcid.org/0009-0002-1567-9629)
Institutions
- Brigham and Women's Hospital (US)
- Harvard University (US)
- Shanghai Jiao Tong University (CN)
- Renji Hospital (CN)
- XinHua Hospital (CN)
- Shanghai Cancer Institute (CN)
- Shanghai First People's Hospital (CN)
Publication Details
- Journal
- Cellular and Molecular Life Sciences
- Published
- 2024-12-24
- DOI
- https://doi.org/10.1007/s00018-024-05497-5
- Citations
- 7
- Primary Topic
- Tryptophan and brain disorders
- Type
- article
- Field-Weighted Citation Impact
- 1.10
Funders
- National Natural Science Foundation of China
- Science and Technology Commission of Shanghai Municipality
- Science and Technology Innovation Plan Of Shanghai Science and Technology Commission