Hydroxycitric acid reconstructs damaged articular cartilages by modifying the metabolic cascade in chondrogenic cells
HCA demonstrates promise as an osteoarthritis therapy by enhancing chondrogenic differentiation. Its ability to modulate crucial metabolic pathways and facilitate cartilage repair suggests potential for clinical translation, addressing a critical need in the treatment of osteoarthritis.
Authors
- Junya Toguchida (ORCID: https://orcid.org/0000-0002-0184-9685)
- Y. Jin (ORCID: https://orcid.org/0000-0002-7095-8295)
- Liping Sun
- Kousuke Tanaka
- Yoshiyuki Mizushina
- Takeshi Kamakura (ORCID: https://orcid.org/0009-0002-4523-8971)
- Sanae Nagata
- Megumi Nishio
- Masayuki Fukuda (ORCID: https://orcid.org/0000-0002-3153-9602)
Institutions
- Kyoto University (JP)
- Kyoto University Hospital (JP)
- Kobayashi Pharmaceutical (Japan) (JP)
Publication Details
- Journal
- Osteoarthritis and Cartilage Open
- Published
- 2024-12-24
- DOI
- https://doi.org/10.1016/j.ocarto.2024.100564
- Citations
- 1
- Primary Topic
- Osteoarthritis Treatment and Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.47