Hippocampal avoidance prophylactic cranial irradiation (HA-PCI) for small-cell lung cancer better preserves white matter networks compared to conventional PCI
While both techniques induce important changes in the WM microstructure, HA-PCI might better preserve the topological organization of brain networks than PCI. The neuroprotective role of hippocampal sparing still needs further investigation.
Authors
- Stefan Sunaert (ORCID: https://orcid.org/0000-0002-1177-4680)
- Michiel B. de Ruiter (ORCID: https://orcid.org/0000-0003-4848-8706)
- Sanne B. Schagen (ORCID: https://orcid.org/0000-0003-0153-8059)
- Jeroen Blommaert (ORCID: https://orcid.org/0000-0002-4746-9688)
- Sabine Deprez (ORCID: https://orcid.org/0000-0001-7451-5355)
- Pim Pullens (ORCID: https://orcid.org/0000-0003-2014-7248)
- Maarten Lambrecht (ORCID: https://orcid.org/0000-0002-8746-2691)
- J. Belderbos (ORCID: https://orcid.org/0000-0002-6434-6436)
- Dirk De Ruysscher (ORCID: https://orcid.org/0000-0002-1214-3557)
- Rob Colaes (ORCID: https://orcid.org/0009-0009-2553-415X)
Institutions
- Allen Institute for Brain Science (US)
- Ghent University Hospital (BE)
- The Netherlands Cancer Institute (NL)
- Maastricht University (NL)
- Institute of Cancer Research (CA)
- VIB-KU Leuven Center for Cancer Biology (BE)
- Oncode Institute (NL)
- VIB-KU Leuven Center for Brain & Disease Research (BE)
- Maastro Clinic (NL)
- University of Amsterdam (NL)
- KU Leuven (BE)
Publication Details
- Journal
- Neuro-Oncology
- Published
- 2024-12-23
- DOI
- https://doi.org/10.1093/neuonc/noae271
- Citations
- 2
- Primary Topic
- Lung Cancer Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.57
Funders
- Fonds NutsOhra
- Vlaamse Liga Tegen Kanker
- Vlaamse regering