DNA Methylation Analysis on Anal Swabs for Anal Cancer Screening in People Living With Human Immunodeficiency Virus
Methylation levels in anal swabs reflect underlying anal disease. Methylation analysis could reduce HRA referrals substantially, while maintaining a high sensitivity for M+ HSIL and detecting all cancers. These results encourage screening on anal swabs to preselect patients needing HRA.
Authors
- Timo J. ter Braak (ORCID: https://orcid.org/0000-0002-7490-0074)
- Philip Meijnen
- Birgit I. Lissenberg‐Witte (ORCID: https://orcid.org/0000-0001-9448-1826)
- Kirsten Rozemeijer (ORCID: https://orcid.org/0000-0002-9597-1728)
- Jan M. Prins (ORCID: https://orcid.org/0000-0002-5415-8933)
- Carel J.M. van Noesel (ORCID: https://orcid.org/0000-0001-7907-7390)
- Stèfanie Dick
- Henry J.C. de Vries (ORCID: https://orcid.org/0000-0001-9784-547X)
- Fernando Dias Gonçalves Lima (ORCID: https://orcid.org/0000-0003-0546-7956)
- Debby Geijsen (ORCID: https://orcid.org/0000-0003-0310-5054)
- Ramon P van der Zee (ORCID: https://orcid.org/0000-0003-1325-1901)
- Renske D.M. Steenbergen (ORCID: https://orcid.org/0000-0002-2327-9839)
Institutions
- Dutch Cancer Society (NL)
- Amsterdam Neuroscience (NL)
- GGD Amsterdam (NL)
- Public Health Service of Amsterdam (NL)
- Amsterdam University Medical Centers (NL)
- Institute of Infection and Immunity (CA)
- Cancer Center Amsterdam (NL)
- Vrije Universiteit Amsterdam (NL)
- University of Amsterdam (NL)
Publication Details
- Journal
- The Journal of Infectious Diseases
- Published
- 2024-12-20
- DOI
- https://doi.org/10.1093/infdis/jiae627
- Citations
- 6
- Primary Topic
- Cervical Cancer and HPV Research
- Type
- article
- Field-Weighted Citation Impact
- 2.32