Diagnostic and prognostic performance of urine ubiquitin carboxy-terminal hydrolase L1 across multiple acute brain injury types – A longitudinal prospective cohort study
Although UCH-L1 concentrations in urine did not differentiate between favorable and unfavorable outcomes, a significant difference was observed between healthy subjects and ABI patients. This finding underscores the significant diagnostic utility of urine UCH-L1 concentrations, regardless of the type of acute brain injury.
Authors
- Romuald Girard (ORCID: https://orcid.org/0000-0002-5893-9315)
- Ying Cao
- Aditya Jhaveri (ORCID: https://orcid.org/0009-0002-1305-0819)
- Eero Ċastrén (ORCID: https://orcid.org/0000-0002-1402-2791)
- Séan Lyne (ORCID: https://orcid.org/0000-0002-9270-7518)
- Janek Frantzén (ORCID: https://orcid.org/0000-0002-6847-5374)
- Fredrika Koskimäki (ORCID: https://orcid.org/0000-0001-7171-3217)
- Riikka S. K. Takala (ORCID: https://orcid.org/0000-0001-6342-0043)
- Jukka Puolitaival
- Tomi Rantamäki (ORCID: https://orcid.org/0000-0002-0052-1434)
- Santtu Hellström
- Melissa Rahi (ORCID: https://orcid.org/0000-0002-8584-4135)
- Antti Sajanti
- Jaakko K. Rinne (ORCID: https://orcid.org/0009-0002-7114-4119)
- Susanna Roine
- Jussi P. Posti (ORCID: https://orcid.org/0000-0002-5925-5193)
- Johannes Falter (ORCID: https://orcid.org/0000-0001-5351-9330)
- Abhinav Srinath (ORCID: https://orcid.org/0000-0001-7336-7231)
- Carolyn M. Bennett (ORCID: https://orcid.org/0000-0002-0866-3090)
- Janne Koskimäki (ORCID: https://orcid.org/0000-0002-2311-6327)
- Miro Jänkälä
- Sulo Kolehmainen
Institutions
- Brigham and Women's Hospital (US)
- University of Helsinki (FI)
- Harvard University (US)
- Oulu University Hospital (FI)
- Helsinki Institute of Physics (FI)
- Turku University Hospital (FI)
- University Medical Center (US)
- University Hospital Regensburg (DE)
- University of Chicago (US)
- University of Regensburg (DE)
Publication Details
- Journal
- Brain and Spine
- Published
- 2024-12-24
- DOI
- https://doi.org/10.1016/j.bas.2024.104173
- Citations
- 4
- Primary Topic
- Traumatic Brain Injury and Neurovascular Disturbances
- Type
- article
- Field-Weighted Citation Impact
- 1.48
Funders
- Suomen Lääketieteen Säätiö
- Academy of Finland
- Sigrid Juséliuksen Säätiö
- Maire Taposen Säätiö