Maternal high glucose and fat diet exposure impaired vascular constriction via miR-325-3P/SHIP2/NOX2 pathway axis in offspring vessels
The present study is the first to demonstrate that maternal HGF diet impairs vascular constriction function in offspring through the miR-325-3p/SHIP2/NOX2 pathway. These novel findings indicate that the detrimental effects of maternal HGF diet on fetal vascular function can persist into adulthood, advancing our knowledge on the impact of maternal diet on offspring vascular health and the early stages of fetal-origin vascular diseases.
Authors
- Qinqin Gao (ORCID: https://orcid.org/0000-0002-1820-7611)
- Bingyu Ji
- Junlan Qiu (ORCID: https://orcid.org/0000-0002-2058-5427)
- Fengying Deng
- Minggang Wei (ORCID: https://orcid.org/0000-0002-1714-6650)
- Bingqing Zhou (ORCID: https://orcid.org/0000-0003-4305-5418)
- Ting Xu (ORCID: https://orcid.org/0000-0003-2578-6532)
- Meihua Zhang (ORCID: https://orcid.org/0000-0002-6821-1168)
- Chenxuan Zhao (ORCID: https://orcid.org/0000-0002-3966-4897)
- Yueming Zhang (ORCID: https://orcid.org/0000-0003-3625-3280)
- Jiahui Lei (ORCID: https://orcid.org/0000-0002-7032-2916)
Institutions
- Qingdao University (CN)
- National Health and Family Planning Commission (CN)
- Soochow University (CN)
- Suzhou Municipal Hospital (CN)
- First Affiliated Hospital of Soochow University (CN)
- Shandong Maternal and Child Health Hospital (CN)
- Nanjing University (CN)
Publication Details
- Journal
- Cellular and Molecular Life Sciences
- Published
- 2024-12-24
- DOI
- https://doi.org/10.1007/s00018-024-05549-w
- Citations
- 2
- Primary Topic
- Birth, Development, and Health
- Type
- article
- Field-Weighted Citation Impact
- 2.22